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Vascular And Neurogenic Rejuvenation In Aging Mice By Modulation Of Asm Pdf

vascular and neurogenic rejuvenation in aging mice by modulation of asm pdf

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Although many studies have reported that the breakdown of the blood-brain barrier BBB represents one of the major pathological changes in aging, the mechanism underlying this process remains relatively unexplored. In this study, we described that acid sphingomyelinase ASM derived from endothelial cells plays a critical role in BBB disruption in aging. ASM levels were elevated in the brain endothelium and plasma of aged humans and mice, resulting in BBB leakage through an increase in caveolae-mediated transcytosis. Mice overexpressing brain endothelial cell-specific ASM exhibited acceleration of BBB impairment and neuronal dysfunction.

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

Sundaram SM, Schwaninger M. Trends Endocrinol Metab. Epub ahead of print. A combined epidemiological-experimental approach. Br J Clin Pharmacol. New mechanistic insights, novel treatment paradigms, and clinical progress in cerebrovascular diseases. Front Aging Neurosci.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Neuron , 27 Sep , 1 : Read article at publisher's site DOI : Biomolecules , 10 10 , 23 Sep

The impact of endothelial cell death in the brain and its role after stroke: A systematic review

Age is associated with altered immune functions that may affect the brain. In this review, we explore novel mechanisms by which the aging immune system alters central nervous system functions and neuroimmune responses, with a focus on brain barriers. Understanding how age alters BBB functions and responses to pathological insults could provide important insight on the role of the BBB in the progression of cognitive decline and neurodegenerative disease. Advances in modern medicine, nutrition, hygiene, and safety standards have doubled the life expectancy of humans worldwide over the last century and a half [ 1 ]. Therefore, it is imperative that the scientific and medical communities investigate approaches that will minimize age-associated disease and maximize quality of life. Age-associated neurological and neurodegenerative diseases are especially debilitating to the afflicted and their families, having tremendous emotional and socioeconomic costs.

Electronic address:. Toggle navigation. Login Categories Journals. Publications by authors named "Minseok Kang". Page 1 of 1. Renin-angiotensin system modulators and other risk factors in COVID patients with hypertension: a Korean perspective.

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.

Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying the transition from a young-and-healthy to aged-and-dysfunctional brain are not well understood. Here, we report breakdown of the vascular blood-brain barrier BBB in aging humans and rodents, which begins as early as middle age and progresses to the end of the life span. Last, we found that this same signaling pathway is activated in aging human subjects with BBB dysfunction.

Cell Stress, Vol. Keywords: apoptosis, autophagy, lysosome-dependent cell death, necroptosis, ischemia, vasculature.

Acid sphingomyelinase-mediated blood-brain barrier disruption in aging

Eur J Endocrinol. Cancers Basel. Aging Dis. Epub Sep Afterdischarges elicited by cortical electric stimulation in humans: When do they occur and what do they mean? Epilepsy Behav.

By cleaving sphingomyelin into ceramide, which is an essential component of plasma membrane microdomains, acid sphingomyelinase Asm pivotally controls cell signaling. Acid sphingomyelinase Asm , which catalyzes the hydrolysis of sphingomyelin to ceramide, is a key enzyme in sphingolipid metabolism. Localized in lysosomes, Asm is translocated to the plasma membrane within a few seconds to minutes upon stress stimuli [ 1 , 2 , 3 ]. In plasma membranes, ceramide clusters into membrane platforms that critically control the activity of signal pathways modifying cell survival and death [ 1 , 2 , 4 , 5 ]. Importantly, the pharmacological inhibition or genetic depletion of Asm in mice conferred protection against cystic fibrosis, lung infection and sepsis [ 15 , 16 ], whereas Asm-dependent and -independent ceramide formation was found to be required for radiation-induced tumor apoptosis [ 10 , 17 ]. Hence, the deactivation of Asm represents a potent strategy for the prevention of cell injury in a wide range of pathologies.

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Попав по назначению, программа фиксировала свое местонахождение в Интернете и передавала его в АНБ, после чего бесследно уничтожала маяк. Начиная с того дня, анонимные переадресующие компании перестали быть для АНБ источником серьезных неприятностей. - Вы сможете его найти? - спросил Стратмор. - Конечно. Почему вы не позвонили мне раньше. - Честно говоря, - нахмурился Стратмор, - я вообще не собирался этого делать. Мне не хотелось никого в это впутывать.

Стратмор был поражен до глубины души. Никто никогда не позволял себе говорить с заместителем директора АНБ в таком тоне. - Сьюзан, - проговорил он, стараясь сдержать раздражение, - в этом как раз все. Мне было нужно… Но тигрица уже изготовилась к прыжку. - В вашем распоряжении двадцать тысяч сотрудников.

Вопрос национальной безопасности. Консьерж покачал головой: - Невозможно. Быть может, вы оставите… - Всего на одну минуту.

Однако Стратмор ничего не объяснил, а Беккер не решился спросить. АНБ, - подумал.  - НБ - это, конечно, не болтай. Вот такое агентство.

Он был принят сегодня утром. Его карточка должна лежать где-то сверху.

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