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Telomeres Telomerase And Cancer Pdf

telomeres telomerase and cancer pdf

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Published: 13.04.2021

Telomeres and Telomerase in Cancer

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial , Introducing OncoTarget. Sponsored Conferences. Impact Journals is a member of the Society for Scholarly Publishing.

Current therapies for breast cancer include treatments that are toxic and often result in drug resistance. Telomerase is thus an attractive target for both diagnosis and therapy because of its distinct pattern of expression. We address the use of telomerase in the diagnostics of breast pathology, as well as the use of telomerase inhibitors in the treatment and prevention of breast cancer. Human chromosomes contain repeated TTAGGG DNA sequences at their ends telomeres that provide genomic stability protect the ends from being recognized as DNA breaks needing repair and a source of expendable DNA a solution to the inability of the replication machinery to copy the extreme ends of chromosomes: the end replication problem see [ 1 ] for a review. A significant amount of truncation can occur during DNA replication without causing deleterious effects. Human telomeres progressively shorten with ongoing cell division until they reach a critical length that induces replicative senescence [ 2 ].

Telomeres and Telomerase in Cancer

Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.

Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor cells has not been examined. Here, we have addressed the role of telomerase activity in the proliferation of human tumor and immortal cells by inhibiting TERT function. Inducible dominant-negative mutants of hTERT dramatically reduced the level of endogenous telomerase activity in tumor cell lines. Clones with short telomeres continued to divide, then exhibited an increase in abnormal mitoses followed by massive apoptosis leading to the loss of the entire population. This cell death was telomere-length dependent, as cells with long telomeres were viable but exhibited telomere shortening at a rate similar to that of mortal cells. It appears that telomerase inhibition in cells with short telomeres lead to chromosomal damage, which in turn trigger apoptotic cell death.

Journal of Cancer. International Journal of Biological Sciences. International Journal of Medical Sciences. Journal of Genomics. Global reach, higher impact.

telomeres telomerase and cancer pdf

PDF | There is mounting evidence for the existence of an important relationship between telomeres and telomerase and cellular aging and cancer. Normal.

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Long telomeres and cancer risk: the price of cellular immortality

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Существовал только один разумный путь - выключить. Чатрукьян знал и то, что выключить ТРАНСТЕКСТ можно двумя способами. Первый - с личного терминала коммандера, запертого в его кабинете, и он, конечно, исключался. Второй - с помощью ручного выключателя, расположенного в одном из ярусов под помещением шифровалки. Чатрукьян тяжело сглотнул.

Она поймала себя на мысли, что глаза ее смотрят в пустоту. Прижавшись лицом к стеклу, Мидж вдруг почувствовала страх - безотчетный, как в раннем детстве. За окном не было ничего, кроме беспросветного мрака.

Telomere and Its Role in Diseases

То есть к понедельнику, с самого утра.

Яд, фальсифицированные результаты вскрытия и так далее.  - Стратмор выдержал паузу.  - Какой была твоя первая реакция, когда я сообщил тебе о смерти Танкадо. Сьюзан нахмурилась. - Я подумала, что АНБ его ликвидировало.

 Надеюсь, это не уловка с целью заставить меня скинуть платье. - Мидж, я бы никогда… - начал он с фальшивым смирением. - Знаю, Чед. Мне не нужно напоминать. Через тридцать секунд она уже сидела за его столом и изучала отчет шифровалки.

Telomerase and breast cancer


  1. Somerville B.

    14.04.2021 at 21:51

    The ends of the eukaryotic chromosomes have special properties when compared with chromosomal ends created by stochastic breakdown.

  2. Normando V.

    22.04.2021 at 17:35

    PDF | On Mar 1, , Carol W. Greider and others published Telomeres, Telomerase and Cancer | Find, read and cite all the research you.

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